Original ArticlesSplenectomy for Children With Thalassemia Total or Partial Splenectomy, Open or Laparoscopic SplenectomyAl-Salem, Ahmed H. FRCI, FACS, FICSAuthor Information Department of Pediatric Surgery, Maternity and Children Hospital, Dammam, Saudi Arabia The author declares no conflict of interest. Reprints: Ahmed H. Al-Salem, FRCI, FACS, FICS, P.O. Box 61015, Qatif 31911, Saudi Arabia (e-mail: email@example.com). Received July 28, 2013 Accepted January 14, 2016 Journal of Pediatric Hematology/Oncology: January 2016 - Volume 38 - Issue 1 - p 1-4 doi: 10.1097/MPH.0000000000000121 Buy Metrics Abstract Splenomegaly and hypersplenism are common complications among children with thalassemia necessitating splenectomy. Thirty-six children (27 β-thalassemia major, 3 Hb H disease, and 6 thalassemia intermediate) had total splenectomy (11 laparoscopic and 13 open splenectomy) or partial splenectomy (12 patients). In the partial splenectomy group, 2 with Hb H required no transfusions. For those with β-thalassemia major who had partial splenectomy (9 patients), there was a reduction in the number of transfusions from a preoperative mean of 15.2 transfusions per year to a postoperative mean of 8.2 transfusions per year. Subsequently and as a result of increase in the size of splenic remnant, their transfusions increased, but none required total splenectomy. Twenty-four patients had total splenectomy (13 open and 11 laparoscopic splenectomy). Their postsplenectomy transfusions decreased from a preoperative mean of 17.8 transfusions per year to a postoperative mean of 10 transfusions per year. There was no mortality, and none developed postoperative sepsis or thrombotic complications. Total splenectomy is beneficial for children with β-thalassemia major and hypersplenism by reducing their transfusion requirements. Laparoscopic splenectomy is however more beneficial. Partial splenectomy reduces their transfusion requirements, but only as a temporary measure, and so it is recommended for children younger than 5 years of age. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.