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Large Cell Neuroendocrine Carcinoma of the Nasopharynx

A Pediatric Case

Dumars, Clotilde MSc*,†; Thebaud, Estelle MD; Joubert, Madeleine MD*; Renaudin, Karine MD*; Cariou-Patron, Gwenaëlle MD§; Heymann, Marie-Françoise PhD, MD*,†

Journal of Pediatric Hematology/Oncology: August 2015 - Volume 37 - Issue 6 - p 474–476
doi: 10.1097/MPH.0000000000000334
Clinical and Laboratory Observations

Neuroendocrine tumors are rare, preferentially located in the gastrointestinal tract or in the lungs. We present the case of a 9-year-old child, presenting with a tissue mass involving the nasopharynx and associated with multiple pulmonary and bone metastases. The immunohistochemical analysis showed a proliferation of large tumor cells stained with Chromogranin A and Synaptophysin. The diagnosis of multimetastatic large cell neuroendocrine carcinoma was made. This tumor is infrequent in this location and particularly in children. This case describes the pathologic aspects and immunohistochemical results and presents a discussion of the differential diagnoses.

*Department of Pathology A, Quai Moncousu RJPT1

Department of Pediatric Hematology and Oncology, Hôpital enfant-adolescent, quai Moncousu

§Department of Otolaryngology-Head and Neck Surgery, Hôtel-Dieu

INSERM, UMR U957, Laboratory of Pathophysiology of Bone Resorption and Therapy of Primary Bone Tumors, Faculty of Medicine, University of Nantes, Nantes Cedex 1, France

The authors declare no conflict of interest.

Reprints: Marie-Françoise Heymann, PhD, MD, Department of Pathology A, Quai Moncousu RJPT1, 44093 Nantes Cedex 1, France (e-mail:

Received June 17, 2014

Accepted February 26, 2015

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