Original ArticlesChildhood Ewing Sarcoma of the OrbitAlfaar, Ahmad S. MBBCh, MSc*,†,‡; Zamzam, Manal MD§; Abdalla, Badr MBBCh†; Magdi, Ranin BPSc, MSc*; El-Kinaai, Naglaa MD∥ Author Information Departments of *Research §Pediatric Oncology ∥Pathology, Children’s Cancer Hospital †Cairo University Hospitals, Faculty of Medicine, Cairo University, Cairo, Egypt ‡Faculty of Medicine, Ulm University, Ulm, Germany The authors declare no conflict of interest. Reprints: Ahmad S. Alfaar, MSc, MD, MBBCh, 1 Sekket Al-Imam Street, SayedaZainab, Cairo 11441, Egypt (e-mail: [email protected]). Received June 30, 2014 Accepted March 26, 2015 Journal of Pediatric Hematology/Oncology: August 2015 - Volume 37 - Issue 6 - p 433-437 doi: 10.1097/MPH.0000000000000346 Buy Metrics Abstract In the span of the last 48 years, only 33 cases of children with orbital Ewing sarcoma have been reported. This study is to present 3 cases that were admitted to Children’s Cancer Hospital Egypt 57357, during the period from 2009 to 2013. We have 2 cases treated using the hospital standard Ewing sarcoma treatment protocol, to completion, whereas the third discontinued treatment. All tumors have confirmed CD99 positivity, although translocation (11;22) was positive in 1 patient and negative in the third. With earlier diagnosis and adequate surgical resection and integration of chemotherapy and radiotherapy 1 patient survived for about 4 years, whereas the other 2 cases died due to disease progression or recurrence. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.