Institutional members access full text with Ovid®

Share this article on:

Image-guided Percutaneous Core Needle Biopsy of Musculoskeletal Tumors in Children

Mitton, Bryan MD, PhD; Seeger, Leanne L. MD; Eckardt, Mark A. BA; Motamedi, Kambiz MD; Eilber, Fritz C. MD; Nelson, Scott D. MD; Eckardt, Jeffrey J. MD; Federman, Noah MD

Journal of Pediatric Hematology/Oncology: July 2014 - Volume 36 - Issue 5 - p 337–341
doi: 10.1097/MPH.0b013e3182880de0
Original Articles

The use of image-guided percutaneous core needle biopsy (PCNB) to obtain tissue diagnosis of musculoskeletal lesions has become the standard of care in adult patients with a success rate of over 80%. Previous reports indicate a similar success rate in diagnosing pediatric solid tumors. In this large study, we analyzed >10 years of data in which PCNB was used for tissue diagnosis of musculoskeletal lesions in children; we evaluated the histopathologic accuracy, anesthetic requirements, and complications of these procedures. In 122 children, tissue diagnosis was successfully obtained in 82% of cases, and there were 0 complications associated with the procedure. There was a significantly higher PCNB diagnostic success rate in malignant lesions (93%). These data suggest that the use of PCNB is a safe and effective means of diagnosing musculoskeletal lesions in children.

*Department of Pediatrics, Division of Pediatric Hematology/Oncology

Department of Medicine, Division of Hematology/Oncology

§Department of Surgery, Division of Surgical Oncology

Departments of Radiology


Orthopedic Surgery, University of California, Los Angeles, Los Angeles CA

N.F. is supported by a St. Baldrick’s Foundation Career Development Award.

The authors declare no conflict of interest.

Reprints: Noah Federman, MD, Department of Pediatrics, Division of Hematology/Oncology, Mattel Children’s Hospital at University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1752 (e-mail:

Received May 23, 2012

Accepted January 15, 2013

Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.