Primary myelofibrosis is rare in children. Many causes have been described for secondary myelofibrosis including vitamin D deficiency. Here, we describe a patient with myelofibrosis secondary to vitamin D deficiency, as diagnosed by laboratory evidence. The patient also developed resultant extramedullary hematopoiesis with secondary development of ascites as a result of myelofibrosis. These are findings rarely reported in association with vitamin D deficiency. Potential mechanisms are also discussed.
*Carman and Ann Adams Department of Pediatrics, Division of Hematology/Oncology
Divisions of ‡Critical Care
§Pathology, Children’s Hospital of Michigan
†Wayne State University, Detroit, MI
The authors declare no conflict of interest.
Reprints: Meret Henry, MD, Carman and Ann Adams Department of Pediatrics, Division of Hematology/Oncology, Children’s Hospital of Michigan, 3901 Beaubien, Detroit, MI 48201 (e-mail: firstname.lastname@example.org).
Received October 1, 2012
Accepted February 20, 2013