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Myelofibrosis, Hepatic Extramedullary Hematopoiesis and Ascites Associated With Vitamin D Deficiency in Early Infancy

Henry, Meret MD; Chitlur, Meera MD; Rajpurkar, Madhvi MD; Mastropietro, Christopher W. MD; Poulik, Janet MD; Ravindranath, Yaddanpuddi MD

Journal of Pediatric Hematology/Oncology: May 2014 - Volume 36 - Issue 4 - p 319–321
doi: 10.1097/MPH.0b013e31828e548a
Clinical and Laboratory Observations

Primary myelofibrosis is rare in children. Many causes have been described for secondary myelofibrosis including vitamin D deficiency. Here, we describe a patient with myelofibrosis secondary to vitamin D deficiency, as diagnosed by laboratory evidence. The patient also developed resultant extramedullary hematopoiesis with secondary development of ascites as a result of myelofibrosis. These are findings rarely reported in association with vitamin D deficiency. Potential mechanisms are also discussed.

*Carman and Ann Adams Department of Pediatrics, Division of Hematology/Oncology

Divisions of Critical Care

§Pathology, Children’s Hospital of Michigan

Wayne State University, Detroit, MI

The authors declare no conflict of interest.

Reprints: Meret Henry, MD, Carman and Ann Adams Department of Pediatrics, Division of Hematology/Oncology, Children’s Hospital of Michigan, 3901 Beaubien, Detroit, MI 48201 (e-mail:

Received October 1, 2012

Accepted February 20, 2013

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