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Variants of Cardiomyopathy and Hypertension in Neuroblastoma

Kwok, Sit Yee MBChB, MRCPCH; Cheng, Frankie Wai Tsoi MD, FHKAM (Paediatrics); Lo, Amy Fung Cheung MBChB, FHKCPaed, FHKAM (Paediatrics); Leung, Wing Kwan MBChB, FHKCPaed, FHKAM (Paediatrics); Yam, Man Ching MBChB, FHKCPaed, FHKAM (Paediatrics); Li, Chi Kong MD, FHKAM (Paediatrics)

Journal of Pediatric Hematology/Oncology: April 2014 - Volume 36 - Issue 3 - p e158–e161
doi: 10.1097/MPH.0b013e318290c628
Clinical and Laboratory Observations

Catecholamine-associated cardiomyopathies caused by neuroblastoma have rarely been reported. We are reporting 2 cases of neuroblastoma associated with hypertension and severe cardiomyopathic changes in different extremes. One case was dilated cardiomyopathy with heart failure, and the other showed echocardiographic features simulating hypertrophic obstructive cardiomyopathy. Both girls had high levels of urine catecholamines on presentation. Anthracycline group of chemotherapy was avoided. Chemotherapy and tumor resection resulted in successful normalization of blood pressure and regression of cardiomyopathic changes. Blood pressure and cardiomyopathic changes should be monitored not only at presentation, but also during the treatment for neuroblastoma.

Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong

The authors declare no conflict of interest.

Reprints: Sit Yee Kwok, MBChB, MRCPCH, Department of Paediatrics, The Chinese University of Hong Kong, 6/F Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region, China (e-mail:

Received September 23, 2012

Accepted March 2, 2013

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