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Bacteremia Due to Imipenem-resistant Roseomonas mucosa in a Child With Acute Lymphoblastic Leukemia

Michon, Anne-Laure PharmD; Saumet, Laure MD; Bourdier, Alice PharmD; Haouy, Stéphanie MD; Sirvent, Nicolas MD, PhD; Marchandin, Hélène PharmD, PhD

Journal of Pediatric Hematology/Oncology: April 2014 - Volume 36 - Issue 3 - p e165–e168
doi: 10.1097/MPH.0b013e318290d503
Clinical and Laboratory Observations
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Roseomonas are described as opportunistic pathogens rarely involved in human infections. Their identification requires molecular methods and their antimicrobial susceptibility pattern varies according to the species. We report the first case of bacteremia due to Roseomonas mucosa in a child with leukemia and reviewed pediatric cases of Roseomonas infection, for which undoubted strain identification was available. Favorable outcome was observed despite resistance to numerous β-lactams that may account for delayed effective treatment, suggesting the low virulence of Roseomonas in children. Here, the strain also displayed unusual resistance to imipenem, highlighting the possible acquisition of additional resistance by this pathogen.

*Unité de Bactériologie Siméon de Buochberg, UMR 5119 ECOSYM, Equipe Pathogènes et Environnements, U.F.R. des Sciences Pharmaceutiques et Biologiques, Université Montpellier 1

Département de Pédiatrie, Unité d’onco-hématologie

Laboratoire de Bactériologie, Hôpital Arnaud de Villeneuve

§Laboratoire d’Hygiène hospitalière, Centre Hospitalier Régional Universitaire de Montpellier, Montpellier, France

Supported in part by ADEREMPHA (Association pour la Recherche et le Développement en Microbiologie & Pharmacie).

The authors declare no conflict of interest.

Reprints: Hélène Marchandin, PharmD, PhD, Unité de Bactériologie Siméon de Buochberg, UMR 5119 ECOSYM, Equipe Pathogènes et Environnements, U.F.R. des Sciences Pharmaceutiques et Biologiques, Université Montpellier 1, 15, Avenue Charles Flahault, BP 14491, 34093 Montpellier, Cedex 5, France (e-mail: helene.marchandin@univ-montp1.fr).

Received October 20, 2012

Accepted March 6, 2013

Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.