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Inflammatory Myofibroblastic Tumors Following the Treatment of Malignancy in Childhood: Case Reports

Adamski, Jennifer K. MBChB, PhD, MD; Kelsey, Anna MBChB, FRCPATH, MD; Brennan, Bernadette MBChB, MD

Journal of Pediatric Hematology/Oncology: March 2014 - Volume 36 - Issue 2 - p 159–162
doi: 10.1097/MPH.0b013e31827e5302
Clinical and Laboratory Observations

Inflammatory myofibroblastic tumors (IMT) are rare, mostly benign soft tissue tumors. Occurring mainly in children the presentation, clinical features, and diagnostic dilemmas raised are well reported. Here we describe 4 patients diagnosed with IMT after the treatment of childhood cancer, and review the literature regarding IMT and malignancy. Discussing them in this context raises clinical questions; Are these tumors incidental or a consequence of treatment? Are they more common than we think and are any miss-diagnosed as tumor recurrence? This paper aims to raise awareness of IMT as diagnostic possibilities after treatment for childhood malignancies.

Royal Manchester Children’s Hospital, Manchester, UK

The authors declare no conflict of interest.

Reprints: Jennifer K. Adamski, MBChB, PhD, MD, Department of Paediatric Oncology, Royal Manchester Children’s Hospital, Oxford Road, Manchester M13 9WL, UK (e-mail:

Received June 25, 2012

Accepted November 15, 2012

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