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A Subcutaneous Paraspinal Yolk Sac Tumor in a Child

Tekgündüz, Sibel A. MD; Bozkurt, Ceyhun MD; Şahin, Gürses MD; Apaydin, Sema MD; Ören, Ayşe C. MD; Balkaya, Eda MD; Ertem, Ayşe U. MD

Journal of Pediatric Hematology/Oncology: March 2014 - Volume 36 - Issue 2 - p e115–e117
doi: 10.1097/MPH.0b013e31829d140a
Online Articles: Clinical and Laboratory Observations

A 3-year-old girl underwent a surgery at an external center on July 2011 for a swelling in the left lumbar paravertebral subcutaneous region. The mass was completely excised and the pathologic diagnosis was a yolk sac tumor (YST). Laboratory tests revealed a serum α-fetoprotein level of 278 IU/mL. Investigations using bone scintigraphy and magnetic resonance imaging revealed a scar tissue at the surgical site and lesions indicating metastasis at the lumbar first, second, third, and fifth vertebra. The patient was administered 5 cycles of PEB (cisplatin, etoposide, bleomycin) treatment. The serum α-fetoprotein was 3 IU/mL after the treatment. The lumbar magnetic resonance imaging and bone scintigraphy results were normal. The patient continues to be in remission since June 2012. YSTs are most commonly seen in the testis, ovary, and sacrococcygeal regions. Atypical locations have been reported with the primary lesion in the stomach, diaphragm, omentum, sino-nasal region, cranial base, lungs, vagina, and penis. Our case is probably a YST with an atypical location derived from preliminary cells left under the skin because of a migration defect.

Departments of *Pediatric Oncology

Pathology, Dr Sami Ulus Children Hospital, Ankara, Turkey

The authors declare no conflict of interest.

Reprints: Sibel A. Tekgündüz, MD, Department of Pediatric Oncology, Dr Sami Ulus Children Hospital, Kardelen Mah. 2107.sok., Botanik Sitesi No:12, Batikent-Yenimahalle, Ankara, Turkey 06370 (e-mail:

Received October 26, 2012

Accepted May 4, 2013

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