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Paraganglioma Presenting With Marked Proteinuria: A Case Report

Emir, Suna MD; Demir, Haci A. MD; Güven, Burcu MD; Kaçar, Ayper MD; Ötkün, İbrahim MD

Journal of Pediatric Hematology/Oncology: January 2014 - Volume 36 - Issue 1 - p e16–e18
doi: 10.1097/MPH.0b013e3182779585
Online Articles: Clinical and Laboratory Observations

Paragangliomas are rare neuroendocrine tumors that arise from sympathetic and parasympathetic paraganglia. In children, most of them are functional tumors. Presenting symptoms such as sustained or paroxysmal elevations in blood pressure, headache, sweating, and palpitations are related to catecholamine hypersecretion. A previously healthy 8-year-old boy presented with marked proteinuria, hypertension, and heart murmur. Imaging revealed an 81×43×45 mm sized solid mass extending from right retroaortic area to left suprarenal region. Measurements of catecholamines suggested the diagnosis of paraganglioma. Pathologic examination confirmed the diagnosis. Complete tumor resection was performed. Proteinuria, hypertension, and cardiac signs resolved after surgery. Proteinuria has been described as a rare manifestation of paragangliomas in adult patients. This is the first case of a paraganglioma presenting with massive proteinuria in a child.

Departments of *Pediatric Hematology Oncology

Pathology, SB Ankara Children’s Hematology Oncology Education and Research Hospital

Department of Pediatric Surgery, Başkent University Faculty of Medicine, Ankara, Turkey

The authors declare no conflict of interest.

Reprints: Suna Emir, MD, Department of Pediatric Hematology Oncology, Acar Beytepe evleri Beytepe Mahallesi 1712, sokak No 1/17 Çankaya, 06800 Ankara, Turkey (e-mail:

Received May 11, 2012

Accepted October 4, 2012

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