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Chronic Residual Lesions in Metastatic Medulloblastoma Patients

Fried, Iris MD; Huang, Annie MD, PhD; Bartels, Ute MD; Tabori, Uri MD; Laperriere, Normand MD; Dirks, Peter MD, PhD; Bouffet, Eric MD

Journal of Pediatric Hematology/Oncology: January 2014 - Volume 36 - Issue 1 - p 71–75
doi: 10.1097/MPH.0b013e3182843b40
Clinical and Laboratory Observations

In a retrospective review of 24 metastatic medulloblastoma patients whose treatment included craniospinal irradiation, 5 patients presented with gross residual abnormalities at completion of therapy. This report describes 2 medulloblastoma patients with persistent residual abnormalities on serial follow-up imaging studies. The patients aged 2 and 2.5 years old at the time of diagnosis underwent surgery followed by multiagent chemotherapy. One patient progressed on therapy and underwent salvage craniospinal radiation. The second showed residual tumor on end of treatment imaging and received low-dose craniospinal irradiation. Despite persistent magnetic resonance imaging findings, the patients are alive and well 13 and 7 years after diagnosis with no further treatment applied. The nature of these residual abnormalities is discussed.

*Neuro-Oncology Program, Division of Paediatric Haematology and Oncology, The Hospital for Sick Children, University of Toronto

Department of Radiation Oncology, Princess Margaret Hospital

§Department of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada

Department of Pediatrics, Hadassah Medical Center, Division of Pediatric Hematology and Oncology, Jerusalem, Israel

The authors declare no conflict of interest.

Reprints: Eric Bouffet, MD, Neuro-Oncology Program, Division of Paediatric Haematology/Oncology, The Hospital for Sick Children, 555 University Ave., Toronto, ON, Canada M5G 1X8 (e-mail:

Received March 22, 2012

Accepted December 20, 2012

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