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Impact of Multiple Prenatal Risk Factors on Newborn Iron Status at Delivery

McLimore, Heather M. BS; Phillips, Alyssa K. BS; Blohowiak, Sharon E. MS; Pham, Daphne Q-D. PhD; Coe, Christopher L. PhD; Fischer, Beth A. PhD; Kling, Pamela J. MD

Journal of Pediatric Hematology/Oncology: August 2013 - Volume 35 - Issue 6 - p 473–477
doi: 10.1097/MPH.0b013e3182707f2e
Clinical and Laboratory Observations

Background: Maternal anemia and several complications of pregnancy can affect fetal iron acquisition.

Aim: Because it is unknown whether the effects of demographic and maternal risk factors (RF) are summative, we examined cord iron status in newborns with multiple RF for acquiring iron deficiency.

Methods: Cord blood indices from healthy control newborns with and without RF for newborn or infant iron deficiency were studied.

Results: Newborns with greater RF had poorer erythrocyte and storage iron status. Poorest status was seen if mothers with comorbid obesity and diabetes delivered large-for-gestation newborns. Findings highlight the importance of identifying RF.

*UW-Madison School of Medicine and Public Health

Department of Pediatrics, Meriter Hospital

§Harlow Center for Biological Psychology, University of Wisconsin, Madison

Department of Biological Sciences, University of Wisconsin-Parkside, Kenosha, WI

Zane State College Institutional Research, Zanesville, OH

Supported by NIH 1 ULRR026011 UW CTSA Program, NIH T32HD048302 Health Disparities Research Scholar (B.A.F.), University of Wisconsin Shapiro Research Program (H.M.M.), University of Wisconsin Cardiovascular Research Center (H.M.M.), Meriter Foundation (P.J.K.), Wisconsin Partnership Collaborative Health Sciences Program Grant (P.J.K., C.L.C., D.Q.D.P), Thrasher Research Fund (P.J.K.), UW Graduate School Competition (P.J.K.), Salary support (C.L.C.) HD057064, HD38305, Gates Foundation OPP1046203).

The authors declare no conflict of interest.

Reprints: Pamela J. Kling, MD, Department of Pediatrics, Meriter Hospital, University of Wisconsin, 202 South Park Street, Madison, WI 53715 (e-mail:

Received March 22, 2012

Accepted August 22, 2012

Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.