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6-Mercaptopurine-induced Recurrent Acute Pancreatitis in Children With Acute Lymphoblastic Leukemia/Lymphoma

Halalsheh, Hadeel MD; Bazzeh, Faiha MD; Alkayed, Khaldoun MD; Salami, Khadra MD; Madanat, Faris MD

Journal of Pediatric Hematology/Oncology: August 2013 - Volume 35 - Issue 6 - p 470–472
doi: 10.1097/MPH.0b013e318271c92f
Clinical and Laboratory Observations

Two children with acute lymphoblastic leukemia/lymphoma developed recurrent acute pancreatitis during treatment; the etiology was presumed to be secondary to 6-mercaptopurine (6MP). Both had no further attacks after discontinuation of 6MP. Acute pancreatitis secondary to 6MP is extremely rare in acute leukemia/lymphoma although it has been reported in patients with other conditions like inflammatory bowel disease; the reason for this difference is not clearly understood.

Department of Pediatric Hematology/Oncology, King Hussein Cancer Center, Amman, Jordan

The authors declare no conflict of interest.

Reprints: Faris Madanat, MD, Department of Pediatric Hematology/Oncology, King Hussein Cancer Center, Queen Rania Al Abdulla Street, P.O. Box 1269, Al-Jubeiha, Amman 11941, Jordan (e-mail:

Received April 3, 2012

Accepted August 29, 2012

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