Inflammatory myofibroblastic tumors are rare tumors characterized as low-to-intermediate grade sarcomas. This is a case of a 7-year-old male with a 5-cm lung mass, which recurred 11 months after complete resection. The recurrence manifested as multifocal metastatic disease involving the ipsilateral parietal and visceral pleura. A novel chemotherapeutic regimen, which included vincristine, ifosfamide, doxorubicin, and celecoxib was utilized for the disease recurrence. The patient had complete and durable remission of the disease and has been disease-free for >4 years. This novel regimen including a cyclooxygenase 2 inhibitor may be an effective regimen for metastatic inflammatory myofibroblastic tumors.
*Department of General Surgery, Mayo Clinic
†Department of Child Health, University of Arizona College of Medicine Phoenix
‡Department of Surgery, University of Arizona College of Medicine
Departments of §Pediatrics and Clinical Pathology
**Center for Cancer and Blood Disorders, Phoenix Children's Hospital
¶Phoenix Children’s Hospital
#Department of Surgery, Division of Thoracic Surgery, Mayo Clinic, Phoenix, AZ
∥Department of Pathology, Mayo Medical School, Rochester, MN
The authors declare no conflict of interest.
Reprints: Michael M. Henry, MD, Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ 85016 (e-mail: MHenry@phoenixchildrens.com).
Received December 19, 2011
Accepted March 10, 2013