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Mucoepidermoid Carcinoma of the Parotid as a Secondary Malignancy After Chemotherapy in a Child With Neuroblastoma

Blatt, Julie MD*,†; Zdanski, Carlton MD; Scanga, Lori MD, PhD§; Rao, Kathleen W. PhD*,∥; Morris, David E. MD; Shockley, William W. MD

Journal of Pediatric Hematology/Oncology: July 2013 - Volume 35 - Issue 5 - p 399–401
doi: 10.1097/MPH.0b013e3182468c55
Clinical and Laboratory Observations

Secondary neoplasms are not reported frequently after neuroblastoma, which until recently was a cancer with limited long-term survival. Although salivary gland tumors in children and adolescents may be idiopathic, they are seen more often after head and neck radiation. We report a child with stage 4 neuroblastoma treated with high-dose multiagent chemotherapy without radiation therapy to his neck who, within 1 year of treatment, developed a low-grade but large and locally aggressive mucoepidermoid carcinoma of his parotid gland further characterized by a t(11;19)(q21;p13.1). Our patient extends the spectrum of secondary neoplasms after neuroblastoma.

*Department of Pediatrics

Division of Pediatric Hematology Oncology

Departments of Otolaryngology/Head and Neck Surgery

§Surgical Pathology

Pathology and Genetics

Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC

The authors declare no conflict of interest.

Reprints: Julie Blatt, MD, Department of Pediatrics, Division of Pediatric Hematology Oncology, University of North Carolina School of Medicine, 170 Manning Dr, POB 1185A CB 7236 Chapel Hill, NC 27599-7236 (e-mail:

Received November 1, 2011

Accepted December 13, 2011

© 2013 by Lippincott Williams & Wilkins.