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Low Serum Lipocalin Levels in Patients With Iron Deficiency Anemia

Malbora, Baris MD*; Avci, Zekai MD*; Gülsan, Meltem MD; Orhan, Betul MD; Ozbek, Namik MD*,†

Journal of Pediatric Hematology/Oncology: April 2013 - Volume 35 - Issue 3 - p 218–220
doi: 10.1097/MPH.0b013e3182756dea
Original Articles

In the recent literature, there are studies on the relationship between anemia and lipocalin, but there is no study regarding the relationship between lipocalin and iron deficiency anemia (IDA) up to date. In this study, we aimed to observe lipocalin levels at admission, and after iron therapy in children with IDA. We also compared our findings to those in healthy children. Sixty-one children admitted in our outpatient clinic were included in the study. Thirty of these children had IDA (study group) and the rest were healthy (control group). Thirty patients, meeting the IDA criteria, received oral ferrous sulfate of 4 mg/kg/d. As soon as the hemoglobin value reached >11 g/dL, half dose of oral ferrous sulfate therapy was continued for another month. Serum lipocalin levels before and after iron therapies were compared. Hematologic parameters and serum lipocalin levels were also compared between the 2 groups. Mean values of serum lipocalin were 31.01±14.46 and 74.77 ng/dL in patients with IDA at admission and at third month of therapy, respectively (P<0.0001). The same figure was 57.35±39.51 ng/dL in the control group. Before treatment, mean values of lipocalin levels in patients with IDA was significantly lower than the control group (P=0.001); however, such a difference was not detected after 3 months of therapy (P=0.102). We suggest that decreased serum lipocalin levels in our patients during iron insufficiency were caused by iron deficiency rather than anemia.

Departments of *Pediatric Hematology

Pediatrics, Faculty of Medicine, Baskent University, Ankara, Turkey

N.O. and B.M.: planned and performed experiments, and wrote the manuscript. Z.A., M.G., and B.O.: performed the experiments.

The authors declare no conflict of interest.

Reprints: Baris Malbora, MD, Department of Paediatrics, Faculty of Medicine, Baskent University, 6. Cadde, No: 72/3, Bahcelievler, 06490 Ankara, Turkey (e-mail:

Received May 13, 2012

Accepted September 20, 2012

© 2013 Lippincott Williams & Wilkins, Inc.