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Sustained Response to Weekly Vinblastine in 2 Children With Pilomyxoid Astrocytoma Associated With Diencephalic Syndrome

Singh, Gurpreet MD; Wei, Xing Chang MD; Hader, Walter MD; Chan, Jennifer A. MD; Bouffet, Eric MD; Lafay-Cousin, Lucie MD, MSc

Journal of Pediatric Hematology/Oncology: March 2013 - Volume 35 - Issue 2 - p e53–e56
doi: 10.1097/MPH.0b013e3182707e67
Online Articles: Original Articles

Diencephalic syndrome (DS) related to hypothalamic/chiasmatic region tumor has mainly been reported with low-grade glioma. We described 2 young children with DS related to pilomyxoid astrocytoma. Despite the recognized more agressive clinical behavior of this histologic subtype, we report successful resolution of DS and sustained tumor response with prolonged use of single-agent vinblastine.

Departments of *Pediatric Hematology Oncology and Bone Marrow Transplantation

Pediatric Radiology

Pediatric Neurosurgery, Alberta Children’s Hospital

§Department of Neuropathology, Calgary Laboratory Services, Calgary, AB

Pediatric Brain Tumor Program, Hospital for Sick Children, Toronto, ON, Canada

E.B. received a grant from the Ontario Institute of Cancer Research (06-NOV-00302 OICR) for the “phase II study of vinblastine in chemotherapy naïve patient.” The remaining authors declare no conflict of interest.

Reprints: Lucie Lafay-Cousin, MD, MSc, Department of Pediatric Hematology Oncology and Bone Marrow Transplantation, Alberta Children’s Hospital, 2888 Shaganappi trail NW Calgary, AB, Canada T3B 6A8 (e-mail:

Received February 16, 2012

Accepted August 22, 2012

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