Short hemato-oncologic procedures are often painful in children, and sedation should be performed outside the operating room.
The study aims to compare the effects of remifentanil with those of fentanyl administered during short hemato-oncologic interventions in children.
A prospective, randomized study was planned for 29 ASA I to III children (aged, 2 to 18 y) to undergo a total of 60 short oncologic interventions. The patients were placed into 2 groups: propofol-remifentanil (group PR) and propofol-fentanyl (group PF). Group PR was first administered propofol (2 mg/kg) and then remifentanil bolus (0.5 μg/kg). Group PF was first administered propofol (2 mg/kg) and then fentanyl bolus (0.5 μg/kg). Systolic arterial pressure, diastolic arterial pressure, mean arterial pressure, respiratory rate, peripheral oxygen saturation, and heart rate were recorded every 3 minutes during the intervention and every 5 minutes after the operation. Postanesthetic recovery scores, eye-opening time to speech, and recovery time were recorded.
Comparison of diastolic arterial pressure in groups at minute 3 of the procedure showed significant difference (P<0.05). Eye-opening to speech (P=0.043) and recovery times (P=0.002) were shorter in group PR.
During short hemato-oncologic interventions in children, the PR combination is a suitable one for early recovery.
Departments of *Anesthesiology and Intensive Care
‡Pediatric Oncology, School of Medicine, Dokuz Eylül University, İzmir, Turkey
Supported by the Department of Anesthesiology and Reanimation and I.E.I.
I.E.I. and L.İ.: designed the study and wrote the protocol. Ş.Y., D.G., M.A., and D.İ.: managed the literature searches, data collection, data interpretation, and undertook the statistical analysis. I.E.I. and L.İ.: wrote the first draft of the manuscript. I.E.I., L.İ, Ş.Y., D.G., M.A., and D.İ. have contributed and have approved the final manuscript.
The authors declare no conflict of interest.
Reprints: Leyla İyilikci, MD, Department of Anesthesiology and Intensive Care, School of Medicine, Dokuz Eylül University, İnciralti 35340, İzmir, Turkey (e-mail: email@example.com).
Received November 29, 2011
Accepted October 17, 2012