Pancreatoblastoma is a rare pediatric pancreatic malignancy. It confers a worse prognosis if there is metastatic or unresectable disease. We report a case of a 12-year-old boy who presented with pancreatoblastoma of the head of the pancreas with multiple intrahepatic metastases. We successfully treated him using aggressive chemotherapy, multi-stage surgery, and gemcitabine chemotherapy, which has not been described as treatment for pancreatoblastoma. Rare childhood malignancies such as pancreatoblastoma require a coordinated, multidisciplinary approach and frequent reassessment of therapeutic interventions. Complete surgical resection is important for cure and may require complex, aggressive, multiple-stage surgical procedures with concurrent or novel chemotherapy.
*Department of Pediatrics, Division of Pediatric Hematology, Oncology and Palliative Care
‡Department of Radiology and Diagnostic Imaging, Division of Pediatric Radiology, Stollery Children’s Hospital
†Department of Surgery, Division of General Surgery, University of Alberta Hospital, University of Alberta, Edmonton, AB, Canada
The authors declare no conflict of interest.
Reprints: Mark J. Belletrutti, MD, Department of Pediatrics, Division of Pediatric Hematology, Oncology, and Palliative Care Stollery Children’s Hospital, 3-511 Edmonton Clinic Health Academy, 11405 87 Avenue NW, Edmonton, AB, Canada T6G 1C9 (e-mail: email@example.com).
Received October 6, 2011
Accepted August 22, 2012