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Mannose-binding Lectin Genotype Influences Frequency and Duration of Infectious Complications in Children With Malignancy

Dommett, Rachel MD, PhD; Chisholm, Julia MD, PhD; Turner, Malcolm DSc, Med, PhD; Bajaj-Elliott, Mona PhD; Klein, Nigel J. MD, PhD

Journal of Pediatric Hematology/Oncology: January 2013 - Volume 35 - Issue 1 - p 69–75
doi: 10.1097/MPH.0b013e31827076e5
Original Articles

Children with cancer receiving identical treatment differ in their experience of infection, suggesting that variations in immunity may influence susceptibility to infection. Studies of the influence of mannose-binding lectin (MBL), an important component of the innate immune system, in children with febrile neutropenia (FN) have yielded conflicting results. We examined the role of MBL in infection susceptibility in the largest cohort of children with cancer reported to date. MBL levels were measured and genotyping performed on children (≤16 y) receiving chemotherapy for cancer in London, UK. Clinical data from FN episodes were recorded prospectively. MBL status was assessed in 269 children; 513 episodes of FN were captured from 211 patients. Patients with MBL2 polymorphisms experienced more FN episodes than wildtype genotype (median 2 vs. 1, respectively; P=0.074) and more episodes with documented infection (P=0.045). Patients experiencing multiple FN episodes had lower MBL levels (P=0.036). MBL genotype influenced duration of episode in some groups: high-risk MBL-deficient patients spent up to 5 nights longer/episode in hospital than equivalent wildtypes. These results indicate that MBL deficiency influences both susceptibility to and outcome of FN episodes and may be most important in those patients at higher risk of complications of FN.

*Infectious Diseases and Microbiology Unit

Immunobiology Unit, Institute of Child Health, University College London, London

Children and Young People’s Department, Royal Marsden Hospital, Sutton, Surrey, UK

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Supported by CRUK. R.D. was in receipt of a PhD studentship supported by the Special Trustees of Great Ormond Street Hospital for Children NHS Trust.

The authors declare no conflict of interest.

Reprints: Nigel J. Klein, MD, PhD, Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, 30 Guilford St., London WC1N 1EH, UK (e-mail:

Received October 26, 2011

Accepted August 22, 2012

Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.