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Endobronchial ALK+ Anaplastic Large-cell Lymphoma Resembling Asthma in a 13-Year-Old Girl

Pavlov, Neven MD, PhD; Pavlov, Vesna MD; Čulić, Srđana MD, PhD; Armanda, Višnja MD; Siebert, Reiner MD; Lozić, Bernarda MD, MSc; Forempoher, Gea MD, PhD; Lukšić, Boris MD, PhD; Perić, Irena MD, PhD; Goic-Barisic, Ivana MD, PhD

Journal of Pediatric Hematology/Oncology: January 2013 - Volume 35 - Issue 1 - p e4–e6
doi: 10.1097/MPH.0b013e31827076c4
Online Articles: Clinical and Laboratory Observations

Anaplastic large-cell lymphoma is a rare disease in children, and endobronchial localization is extremely rare in any age group. We report the case of a 13-year-old girl with endobronchial anaplastic lymphoma kinase–positive anaplastic large-cell lymphoma presenting as asthma, and discuss the diagnostic, therapeutic, and clinical implications.

*Department of Paediatric

Neonatology Unit, Gynecology and Obstetric Clinic

§Clinical Department for Pathology

Clinical Department of Infectious Diseases

Pulmology Clinic

#Clinical Department for Microbiology and Parasitology, Split University Hospital Center, Medical School University of Split, Split, Croatia

Institute of Human Genetics, Christian-Albrechts-University Kiel & University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

R.S. has been supported for research on pediatric ALK+ALCL by the Jose-Carreras-Foundation and receives infrastructural support by the KinderKrebsInitiative Buchholz/Holm-Seppensen.

The authors declare no conflict of interest.

Reprints: Ivana Goic-Barisic, MD, PhD, Clinical Department for Microbiology and Parasitology, Split University Hospital Center, University Hospital of Split, Spinciceva 1, Split 21000, Croatia (e-mail:

Received September 28, 2011

Accepted August 22, 2012

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