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t(6;9)(p23;q34) Presenting Acute Myeloid Leukemia in a Child With an Unsuspected 45,X/46,X,derY [?t(Yp;Yq)] Chromosomal Constitution: Yet Another Y Chromosome Overdosage and Malignancy Association

Ogur, Gönül MD; Duru, Feride MD; Ozyurek, Emel MD; Fisgin, Tunc MD

Journal of Pediatric Hematology/Oncology: August 2012 - Volume 34 - Issue 6 - p e237–e240
doi: 10.1097/MPH.0b013e318238866f
Online Articles: Clinical and Laboratory Observations

Development of leukemia in patients with sexual chromosome abnormalities is relatively rare and mostly involves cases of monosomy X, Turner syndrome. Here, we report on a child having a 45,X/46,X,derY [?t(Yp;Yq)] chromosomal constitution (variant Turner syndrome) presenting with concordant acute myeloid leukemia and a rarely seen clonal neoplasic cell lineage-related karyotype, t(6;9)(p23;q34).

*Department of Pediatric Genetics, Ondokuz Mayis University Medical Faculty

Department of Pediatric Hematology, Ondokuz Mayis University Medical Faculty, Samsun, Turkey

The authors declare no conflict of interest.

Reprints: Gönül Ogur, MD, Department of Pediatric Genetics, Ondokuz Mayis University Medical Faculty, Kurupelit, 55139 Samsun, Turkey (e-mail:

Received April 11, 2011

Accepted September 19, 2011

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.