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Acute Monoblastic Leukemia That Switched Lineage at Relapse to Acute Lymphoblastic Leukemia: A Case Report

Inoue, Akiko MD, PhD; Kawakami, Chihiro; Takitani, Kimitaka; Ikemoto, Toshiyuki; Tamai, Hiroshi

Journal of Pediatric Hematology/Oncology: August 2012 - Volume 34 - Issue 6 - p e258–e260
doi: 10.1097/MPH.0b013e318233219d
Online Articles: Clinical and Laboratory Observations

We herein present the case of an acute monoblastic leukemia infant who relapsed with acute lymphoblastic leukemia (ALL). Complete remission was achieved after an acute myeloblastic leukemia-directed chemotherapy, but the patient relapsed with pro-B ALL. As he did not respond to acute myeloblastic leukemia-type reinduction therapy, he was switched to ALL-type chemotherapy, and a complete remission was achieved. Unrelated cord blood stem cell transplantation was performed, but he relapsed with pro-B ALL again. After he received ALL-type chemotherapy, he underwent another bone marrow transplant from his human leukocyte antigen mismatch mother, and has been free from recurrence for over 8 months.

*Department of Pediatrics

Department of Laboratory Medicine, Osaka Medical College, Takatsuki Japan

The authors declare no conflict of interest.

Reprints: Akiko Inoue, MD, PhD, Department of Pediatrics, Osaka Medical College, 2-7, Daigakumachi, Takatsuki, Osaka 569-8686, Japan (e-mail:

Received June 10, 2011

Accepted August 16, 2011

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.