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Successful Treatment of an Adolescent With Locally Advanced Cervicovaginal Clear Cell Adenocarcinoma Using Definitive Chemotherapy and Radiotherapy

Ansari, Dominic O. MD, PhD; Horowitz, Ira R. MD; Katzenstein, Howard M. MD; Durham, Megan M. MD; Esiashvili, Natia MD

Journal of Pediatric Hematology/Oncology: July 2012 - Volume 34 - Issue 5 - p e174–e176
doi: 10.1097/MPH.0b013e318257dc91
Online Articles: Original Articles

Pediatric cervicovaginal clear cell adenocarcinoma (CCA) is rare but continues to occur in the postdiethylstilbestrol era. Ideal management is unclear. We report a case of locally advanced, node-negative CCA in a 14-year-old girl without a history of diethylstilbestrol exposure. The patient’s disease was FIGO stage IIIA, involving the cervix, vagina, and parametrium. She was treated with concurrent cisplatin and external beam radiation, followed by interstitial low-dose rate brachytherapy. The patient has no evidence of disease after 2 years of follow-up. These findings support the use of definitive chemoradiation as a treatment option for adolescents with locally advanced CCA.

*Department of Radiation Oncology

Department of Gynecology and Obstetrics

§Department of Pediatrics, Division of Pediatric Hematology/Oncology

Department of Surgery, Division of Pediatric Surgery, Emory University School of Medicine

Aflac Cancer Center and Blood Disorders Service of Children’s Healthcare of Atlanta, Atlanta, GA

The authors declare no conflict of interest.

Reprints: Natia Esiashvili, MD, Department of Radiation Oncology, Emory University School of Medicine, 1365 Clifton Rd NE, Atlanta, GA 30322 (e-mail:

Received February 15, 2011

Accepted December 27, 2011

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.