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Successful Treatment of Childhood Hypocellular Acute Myeloid Leukemia

Yamamoto, Masaki MD; Hori, Tsukasa MD, PhD; Hatakeyama, Naoki MD, PhD; Igarashi, Keita MD; Iesato, Kotoe MD; Nakanishi, Katsuya MD, PhD; Noguchi, Hiroko MD, PhD; Miyachi, Hayato MD, PhD; Ito, Masafumi MD, PhD; Tsutsumi, Hiroyuki MD, PhD; Suzuki, Nobuhiro MD, PhD

Journal of Pediatric Hematology/Oncology: July 2012 - Volume 34 - Issue 5 - p 398–401
doi: 10.1097/MPH.0b013e3182388966
Clinical and Laboratory Observations

Hypocellular acute myeloid leukemia (AML) is extremely rare in childhood. We report on a 7-year-old girl with hypocellular AML who was treated successfully with granulocyte-colony stimulating factor (G-CSF) and combined chemotherapy. High-dose G-CSF induced complete remission and she subsequently received reduced intensity conditioning and unrelated cord blood transplantation; however, this resulted in early rejection. After a complete hematological recovery, she received 3 courses of combination chemotherapy oriented toward AML. She has remained in complete remission for over 1 year after the completion of the therapy. G-CSF effectively induced remission, and combination chemotherapy has been proven to be feasible for patients with childhood hypocellular AML.

*Department of Pediatrics

Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo

Department of Laboratory Medicine, Tokai University School of Medicine, Kanagawa

§Department of Pathology, Japanese Red Cross, Nagoya Daiichi Hospital, Nagoya, Japan

Author contribution: Masaki Yamamoto, Hiroyuki Tsutsumi, Naoki Hatakeyama, Keita Igarashi, Kotoe Iesato, and Nobuhiro Suzuki treated the patient. Masaki Yamamoto, Hiroyuki Tsutsumi, and Nobuhiro Suzuki wrote the paper. Katsuya Nakanishi, Hiroko Noguchi, Hayato Miyachi, and Masafumi Ito contributed to the pathological diagnosis. Nobuhiro Suzuki, Naoki Hatakeyama, KI, and Hiroyuki Tsutsumi contributed vital new reagents or analytical tools.

This case was presented at the 52th Annual Meeting of the Japanese Society of Pediatric Hematology, December 16 to 18, 2010, Osaka, Japan.

The authors declare no conflict of interest.

Reprints: Masaki Yamamoto, MD, Department of Pediatrics, Sapporo Medical, University School of Medicine, S1W16 Chuo-ku, Sapporo, 060-8543, Japan (e-mail:

Received March 29, 2011

Accepted September 19, 2011

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.