Although childhood acute lymphoblastic leukemias are of good prognosis than leukemias of adulthood, some chromosomal abnormalities may have negative effects on their prognosis. Inverted duplication (1q) is a chromosomal abnormality with negative effect on outcome of Burkitt leukemia and lymphomas. We report a case of CD20+ Burkitt leukemia with inverted duplication (1q) mutation, who had an early relapse during NHL-BFM 95 treatment. Two courses of ICE-rituximab treatment were administered after relapse and a successful HLA-full match bone marrow transplantation was carried out. He is in follow-up for 18 months without any problem after the bone marrow transplantation. We suggest the usage of ICE protocol combined with rituximab in childhood CD20+ Burkitt leukemia with poor prognostic criteria such as inverted duplication (1q) mutation.
*Departments of Pediatric Hematology
†Pediatrics, Baskent University Faculty of Medicine
‡Department of Pediatric Hematology, Gulhane Military Medical Academy, Ankara, Turkey
The authors declare no conflict of interest.
Reprints: Baris Malbora, MD, Baskent University Department of Pediatrics, 6. Cadde, No: 72/3, 06490, Bahcelievler, Ankara, Turkey (e-mail: email@example.com).
Received February 21, 2011
Accepted August 16, 2011