Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Successful Treatment of ICE-Rituximab Chemotherapy and Subsequent Bone Marrow Transplantation in a Patient With Early-relapse Burkitt Leukemia and Inverted Duplication of 1q

Malbora, Baris MD; Avci, Zekai MD; Olgac, Asburce MD; Gursel, Orhan MD; Kurekci, Emin; Ozbek, Namik

Journal of Pediatric Hematology/Oncology: March 2012 - Volume 34 - Issue 2 - p e84–e85
doi: 10.1097/MPH.0b013e318236b1af
Online Articles: Clinical and Laboratory Observations

Although childhood acute lymphoblastic leukemias are of good prognosis than leukemias of adulthood, some chromosomal abnormalities may have negative effects on their prognosis. Inverted duplication (1q) is a chromosomal abnormality with negative effect on outcome of Burkitt leukemia and lymphomas. We report a case of CD20+ Burkitt leukemia with inverted duplication (1q) mutation, who had an early relapse during NHL-BFM 95 treatment. Two courses of ICE-rituximab treatment were administered after relapse and a successful HLA-full match bone marrow transplantation was carried out. He is in follow-up for 18 months without any problem after the bone marrow transplantation. We suggest the usage of ICE protocol combined with rituximab in childhood CD20+ Burkitt leukemia with poor prognostic criteria such as inverted duplication (1q) mutation.

*Departments of Pediatric Hematology

Pediatrics, Baskent University Faculty of Medicine

Department of Pediatric Hematology, Gulhane Military Medical Academy, Ankara, Turkey

The authors declare no conflict of interest.

Reprints: Baris Malbora, MD, Baskent University Department of Pediatrics, 6. Cadde, No: 72/3, 06490, Bahcelievler, Ankara, Turkey (e-mail:

Received February 21, 2011

Accepted August 16, 2011

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.