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Successful Treatment of ICE-Rituximab Chemotherapy and Subsequent Bone Marrow Transplantation in a Patient With Early-relapse Burkitt Leukemia and Inverted Duplication of 1q

Malbora, Baris MD; Avci, Zekai MD; Olgac, Asburce MD; Gursel, Orhan MD; Kurekci, Emin; Ozbek, Namik

Journal of Pediatric Hematology/Oncology: March 2012 - Volume 34 - Issue 2 - p e84–e85
doi: 10.1097/MPH.0b013e318236b1af
Online Articles: Clinical and Laboratory Observations
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Although childhood acute lymphoblastic leukemias are of good prognosis than leukemias of adulthood, some chromosomal abnormalities may have negative effects on their prognosis. Inverted duplication (1q) is a chromosomal abnormality with negative effect on outcome of Burkitt leukemia and lymphomas. We report a case of CD20+ Burkitt leukemia with inverted duplication (1q) mutation, who had an early relapse during NHL-BFM 95 treatment. Two courses of ICE-rituximab treatment were administered after relapse and a successful HLA-full match bone marrow transplantation was carried out. He is in follow-up for 18 months without any problem after the bone marrow transplantation. We suggest the usage of ICE protocol combined with rituximab in childhood CD20+ Burkitt leukemia with poor prognostic criteria such as inverted duplication (1q) mutation.

*Departments of Pediatric Hematology

Pediatrics, Baskent University Faculty of Medicine

Department of Pediatric Hematology, Gulhane Military Medical Academy, Ankara, Turkey

The authors declare no conflict of interest.

Reprints: Baris Malbora, MD, Baskent University Department of Pediatrics, 6. Cadde, No: 72/3, 06490, Bahcelievler, Ankara, Turkey (e-mail: barismalbora@gmail.com).

Received February 21, 2011

Accepted August 16, 2011

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.