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Multiple Persistent Ganglioneuromas Likely Arising From the Spontaneous Maturation of Metastatic Neuroblastoma

Rozmus, Jacob MD; Langer, Monica MD; Murphy, James J. MD; Dix, David MB ChB

Journal of Pediatric Hematology/Oncology: March 2012 - Volume 34 - Issue 2 - p 151–153
doi: 10.1097/MPH.0b013e318221ca82
Clinical and Laboratory Observations

A 10-year-old girl with multiple persistent ganglioneuromas originating from the spontaneous maturation of a metastatic neuroblastoma is described. Multiple biopsies confirm progressive maturation and urine catecholamines, which were initially elevated, have normalized over time. The management and risk of malignant transformation of ganglioneuromas is discussed.

*Division of Hematology/Oncology/BMT

Division of Pediatric General Surgery, Department of Pediatrics, Faculty of Medicine, University of British Columbia/BC Children's Hospital, Vancouver, British Columbia, Canada

The authors declare no conflict of interest.

Reprints: Jacob Rozmus, MD, Division of Hematology/Oncology/BMT, BC Children's Hospital, Room A119, 4480 Oak St, Vancouver, BC V6H 3V4, Canada (e-mail:

Received September 28, 2010

Accepted April 27, 2011

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.