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Cyto-Morphologic Evaluation of Bone Marrow in Infants With Disseminated Neuroblastoma

Sorrentino, Stefania MD; Rosanda, Cristina PhD; Parodi, Stefano PhD; Rita Gigliotti, Anna MD; Pasino, Mirella PhD; Defferrari, Raffaella PhD; Paolo Tonini, Gian PhD; De Bernardi, Bruno MD

Journal of Pediatric Hematology/Oncology: March 2012 - Volume 34 - Issue 2 - p 154–158
doi: 10.1097/MPH.0b013e3182281dc3
Clinical and Laboratory Observations

We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI.

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*Department of Haematology-Oncology, Giannina Gaslini Children’s Hospital

Clinical Epidemiology Unit, Department of Epidemiology and Prevention

Translational Oncopathology and Laboratory of the Italian Neuroblastoma Foundation, National Cancer Research Institute, Genova, Italy

Supported in part by the Italian Neuroblastoma Foundation and by a research fund provided by the Giannina Gaslini Children’s Hospital, Genova, Italy. Stefano Parodi and Raffaella Defferrari are recipients of an Italian Neuroblastoma Foundation grant.

The authors declare no conflict of interest.

Reprints: Stefania Sorrentino, MD, Department of Hematology-Oncology, Giannina Gaslini Children's Hospital, Largo Gerolamo Gaslini 5, 16147 Genoa, Italy (

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Received November 28, 2010

Accepted June 7, 2011

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.