Clinical and Laboratory ObservationsWilms Tumor Five-year Tumor-free Survival on a Modified SIOP Protocol From an Indian University HospitalTrehan, Amita MD; Chowdhary, Sujit K. FRCS; Marwaha, Ram K. MDAuthor Information *Division of Paediatric Haematology Oncology, Advanced Paediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh †Department of Paediatric Surgery, Apollo Hospital, Sarita Vihar, New Delhi, India The authors declare no conflict of interest. Reprints: Amita Trehan, MD, Division of Paediatric Haematology Oncology, Advanced Paediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India(e-mail: [email protected]). Received July 20, 2009 Accepted July 2, 2010 Journal of Pediatric Hematology / Oncology: January 2012 - Volume 34 - Issue 1 - p 57-62 doi: 10.1097/MPH.0b013e3181f46840 Buy Metrics Abstract Background and Purpose Wilms tumor is one of the most common solid malignancies of childhood. The long-term result of the surgical treatment of this tumor with adjuvant chemotherapy and radiation has been reported from many western centers. However, there is paucity of literature on the long-term outcome of treatment for this tumor from the developing world. We planned a prospective study that started in 1999 to evaluate the 5-year tumor-free survival of Wilms tumor treated on a fixed protocol from a university hospital in India. Methods All consecutive children with Wilms tumor who were seen by any of the 3 investigators (2 pediatric oncologists, 1 pediatric surgeon) between 1999 and 2003 at the Advanced Pediatric Centre were included in the study. Each patient was entered into a database. Their demographic profile and events during the treatment and follow-up were recorded. This was later analyzed. Conclusions Seventy-five percent 5-year tumor-free survival has been achieved within the limitations of treatment in the developing world. The morbidity during therapy was 10% and the mortality 5%. This was based on the treatment of this common childhood malignancy at Chandigarh on a modified International Society of Pediatric Oncology protocol. Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.