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Anthracycline-induced Cardiac Toxicity More Likely in Underweight Childhood Cancer Survivors

Andolina, Jeffrey R. MD; Dilley, Kimberley MD, MPH

Journal of Pediatric Hematology/Oncology: July 2010 - Volume 32 - Issue 5 - p 411-415
doi: 10.1097/MPH.0b013e3181dccd37
Clinical and Laboratory Observations

Background We did a retrospective medical record and echocardiogram review of patients with history of anthracyclines and/or radiation seen in a long-term survivor clinic from 2000-2007.

Observations Three hundred eight out of three hundred seventy (83.2%) patients had received at least 1 screening echocardiogram, and 24/308 (7.8%) patients had an abnormal echocardiogram. Observed risk factors for a future abnormal echocardiogram included anthracycline dose ≥250 mg/m2 and underweight status (BMI <5th%) at follow-up. Age, gender, radiation, anthracycline type, history of relapse, and history of stem cell transplant were not risk factors.

Conclusions Our results confirm the dose-dependent risk of anthracyclines, and describe a novel association with underweight status.

Children's Memorial Hospital, Chicago, IL

Reprints: Jeffrey R. Andolina, MD, Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614 (e-mail:

Received for publication June 19, 2009; accepted February 15, 2010

© 2010 Lippincott Williams & Wilkins, Inc.