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Association Between the Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia in Serbian Children

Damnjanovic, Tatjana MD, MSc*; Milicevic, Radomir MSc; Novkovic, Tanja MSc; Jovicic, Olivera DDS; Bunjevacki, Vera PhD*; Jekic, Biljana PhD*; Lukovic, Ljiljana PhD*; Novakovic, Ivana MD, PhD*; Redzic, Danka MD, PhD; Milasin, Jelena PhD

Journal of Pediatric Hematology/Oncology: May 2010 - Volume 32 - Issue 4 - p e148-e150
doi: 10.1097/MPH.0b013e3181cbd252
Online Articles: Clinical and Laboratory Observations

Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation. Polymorphisms in the MTHFR gene have been associated with susceptibility to some types of cancer. We investigated a possible association of MTHFR polymorphisms (677C>T and 1298A>C) and increased risk for acute lymphoblastic leukemia in 78 affected children. The frequencies of both MTHFR 677 genotypes and alleles were significantly different between patients and controls. A significant association between CT/TT individuals and reduced risk of acute lymphoblastic leukemia was found. The odds ratios were 0.53 (95% confidence interval, 032-0.89) and 0.30 (95% confidence interval, 0.12-0.81). Polymorphism 1298 did not show statistical difference between patients and controls.

*School of Medicine

School of Dentistry, Institute of Human Genetics

Mother and Child Health Institute, Belgrade, Serbia

Supported by the Serbian Ministry of Science, Grant 145075.

Reprint: Jelena Milasin, PhD, School of Dentistry, Institute of Human Genetics, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia (e-mail:

Received for publication April 15, 2009; accepted November 19, 2009

© 2010 Lippincott Williams & Wilkins, Inc.