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The Metabolic Syndrome in Adult Survivors of Childhood Cancer, a Review

van Waas, Marjolein MSc*; Neggers, Sebastian J. MD* †; van der Lelij, Aart-Jan MD, PhD; Pieters, Rob MD, PhD*; van den Heuvel-Eibrink, Marry M. MD, PhD*

Journal of Pediatric Hematology/Oncology: April 2010 - Volume 32 - Issue 3 - p 171-179
doi: 10.1097/MPH.0b013e3181d419c3
Medical Progress

The number of adult survivors of childhood cancer in the general population has increased. As reports on the prevalence of the metabolic syndrome in adult survivors of childhood cancer are scarce, we reviewed the available literature on the components of the metabolic syndrome in adult survivors of childhood cancer. Although there is a lack of studies estimating the prevalence of metabolic syndrome directly, especially prevalence of insulin resistance, obesity, and dyslipidemia is increased in certain groups. Therefore, adult survivors of childhood cancer are at increased risk of developing cerebrovascular and cardiovascular diseases. Accordingly, it is important to identify the predisposing factors of the metabolic syndrome in cohorts of survivors, to introduce medical interventions, and to subsequently decrease the risk of cerebrovascular and cardiovascular events.

*Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital Rotterdam

Department of Medicine, Section Endocrinology, Erasmus University Medical Centre, The Netherlands

Reprints: Marry M. van den Heuvel-Eibrink, MD, PhD, Erasmus MC-Sophia Children's Hospital, Room Sp-2568, PO Box 2060, 3000 CB Rotterdam, the Netherlands (e-mail:

Received for publication May 20, 2009; accepted January 13, 2009

© 2010 Lippincott Williams & Wilkins, Inc.