Original ArticlesErythrocyte Transfusions and Serum Prohepcidin Levels in Premature Newborns With Anemia of PrematurityYapakç, Ece MDı; Ecevit, Ayşe MD; Gökmen, Zeynel MD; Tarcan, Aylin MD; Özbek, Namk MDıAuthor Information Department of Pediatrics, Baskent University Faculty of Medicine, Ankara Turkey Reprints: Aylin Tarcan, MD, 6. cadde 70/4, Bahçelievler, Turkey (e-mail: firstname.lastname@example.org). Received for publication April 14, 2009; accepted July 24, 2009 Journal of Pediatric Hematology/Oncology: November 2009 - Volume 31 - Issue 11 - p 840-842 doi: 10.1097/MPH.0b013e3181b91667 Buy Metrics Abstract Hepcidin is a regulatory peptide hormone acts by limiting intestinal iron absorption and promoting iron retention. Determining the level of hepcidin in anemia of prematurity might be important in preventing iron overload. This study aimed to determine serum levels of prohepcidin in newborns with anemia of prematurity, to assess the effect of a single erythrocyte transfusion on serum prohepcidin levels, and to determine the possible relationships between prohepcidin levels and serum iron and complete blood count parameters. Nineteen premature newborns with anemia of prematurity who had been treated with erythrocyte transfusions were included in this study. Just before, and 48 hours after, each transfusion, venous blood samples were collected from patients. Serum prohepcidin levels before and after erythrocyte transfusion were 206.5±27.3 and 205.7±47.1 ng/mL, respectively; no statistically significant differences were found. No significant differences existed before or after transfusion regarding serum total iron and ferritin levels, iron-binding capacity, or mean corpuscular hemoglobin concentration. No significant correlations existed between serum prohepcidin levels and other parameters, either before or after transfusions. Our results showed that there were no statistically significant differences between serum prohepcidin levels before and after a single erythrocyte transfusion in premature newborns. © 2009 Lippincott Williams & Wilkins, Inc.