Clinical and Laboratory ObservationsDiffuse Neonatal Hemangiomatosis Treatment With Cyclophosphamide: A Case ReportVlahovic, Aleksandar MD*; Simic, Radoje MD*; Djokic, Dragomir MD†; Ceran, Candemir MD‡Author Information Divisions of *Pediatric surgery, Department of Plastic Surgery and Burns †Pediatric Hematology-Oncology, Department of Hematology-Oncology, Institute for Mother and Child Health Care of Serbia, New Belgrade, Serbia ‡Division of Plastic, Reconstructive and Aesthetic Surgery, Ataturk Training and Research Hospital, Bilkent Yolu, Ankara, Turkey Reprints: Aleksandar Vlahovic, MD, Borivoja Stevanovica 10v, Vozdovac, Belgrade 11050, Serbia (e-mail: email@example.com). Received for publication March 4, 2009; accepted June 9, 2009 Journal of Pediatric Hematology/Oncology: November 2009 - Volume 31 - Issue 11 - p 858-860 doi: 10.1097/MPH.0b013e3181b536ad Buy Metrics Abstract We present 3-month-old male infant with diffuse neonatal hemangiomatosis. There were 63 cutaneous hemangiomas over the scalp, face, trunk, and extremities. Computed tomography scan revealed the presence of hemangiomas in the liver and kidneys; laryngobronchoscopy identified the presence of hemangioma in tracheobronchial tree. The child had symptoms of heart failure therefore digitals and diuretics were administrated. Thyroid functions were normal. Treatment with corticosteroids, in dose of 3 mg/kg/d intravenously, was initiated. As there was no significant clinical improvement, cyclophosphamide was administrated. He received 4 courses, 10 days apart. Each course consisted of 10 mg/kg/d of cyclophosphamide and 10 mg/kg/d of mesna for 4 consecutive days. After 4 cycles of cyclophosphamide, the liver was notably decreased in size and the cardiac failure was resolved. Magnetic resonance imaging of the abdomen revealed the marked decrease in size of the liver hemangioma. After 3 years of follow-up the child is well developed, fully recovered, without cardiologic or respiratory problems. © 2009 Lippincott Williams & Wilkins, Inc.