Clinical and Laboratory ObservationsDetection and Clinical Relevance of BCR-ABL Fusion Gene in Childhood T-lineage Acute Lymphoblastic Leukemia: A Report on 4 CasesSazawal, Sudha PhD*; Bakhshi, Sameer MD†; Raina, Vinod MD†; Swaroop, Chetanya MD†; Saxena, Renu MD*Author Information Departments of *Haematology †Medical Oncology, Dr B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India Reprints: Sudha Sazawal, PhD, Department of Haematology, Dr B.R. Ambedkar Institute Rotary Cancer Hospital Building (First Floor), All India Institute Medical Sciences, New Delhi 110029, India (e-mail: firstname.lastname@example.org). Received for publication April 22, 2008; accepted October 29, 2008 Journal of Pediatric Hematology/Oncology: November 2009 - Volume 31 - Issue 11 - p 850-852 doi: 10.1097/MPH.0b013e3181b78502 Buy Metrics Abstract The bcr-abl rearrangement has rarely been reported in T-lineage acute lymphoblastic leukemia and the clinical significance of this translocation is currently unknown. We screened 28 children with T-lineage acute lymphoblastic leukemia at diagnosis by reverse transcription polymerase chain reaction for major and minor break point regions of bcr-abl fusion gene. Four out of 28 patients (14.2%) were bcr-abl positive for the minor breakpoint transcript. One of these patients was refractory to therapy, whereas the other 3 relapsed on therapy. © 2009 Lippincott Williams & Wilkins, Inc.