Original ArticlesComparison of Safety and Effectiveness of Two Different Transfusion Rates in Children With Severe AnemiaOlgun, Hasim MD*; Buyukavci, Mustafa MD†; Sepetcigil, Oguzhan MD‡; Yildirim, Zuhal Keskin MD‡; Karacan, Mehmet MD*; Ceviz, Naci MD*Author Information *Division of Pediatric Cardiology †Division of Pediatric Oncology ‡Department of Pediatrics, Ataturk University, Medical School, Erzurum, Turkey Reprints: Mustafa Buyukavci, MD, Ataturk Universitesi Tip Fakultesi Cocuk Sagligi ve Hastaliklari Klinigi, 25240, Erzurum Turkey (e-mail: email@example.com). Received for publication November 12, 2008; accepted May 13, 2009 Journal of Pediatric Hematology/Oncology: November 2009 - Volume 31 - Issue 11 - p 843-846 doi: 10.1097/MPH.0b013e3181b27073 Buy Metrics Abstract We compared the safety and efficacy of 2 transfusion regimens in children with severe anemia (hemoglobin <5 g/dL) and without overt signs of congestive heart failure requiring transfusion of packed red blood cells (PRBCs). Forty-three patients were randomly divided into 2 groups: group A and group B. The transfusion regimens consisted of continuous infusion of PRBC at a rate of 1 mL/kg/h for group A and 3 mL/kg/h for group B. The patients were closely monitored for any clinical signs of heart failure throughout transfusion. Heart and respiratory rate, and arterial blood pressure were measured hourly for 6 hours during transfusion. None of the patients developed any signs of cardiac failure during or after the transfusion. The mean heart rate, respiratory rate, diastolic and systolic blood pressure were similar in both groups throughout transfusion. Group A needed significantly more PRBC units than group B to attain the same hemoglobin increase. Transfusion of PRBC at a rate of 3 mL/kg/h, and at a rate of 1 mL/kg/h, is a safe regimen for children with severe anemia of gradual onset requiring transfusion therapy. © 2009 Lippincott Williams & Wilkins, Inc.