Original ArticlesImpact of the MTHFR C677T Polymorphism on Risk of Wilms Tumor: Case-Control StudyFerrara, Mara MD; Capozzi, Laura MD; Russo, Rosa MDAuthor Information Department of Pediatrics, Second University of Naples, Naples, Italy Reprints: Mara Ferrara, MD, Second University of Naples, Naples, Italy (e-mail: [email protected]). Received for publication October 12, 2007; accepted November 2, 2008 Journal of Pediatric Hematology/Oncology: April 2009 - Volume 31 - Issue 4 - p 256-258 doi: 10.1097/MPH.0b013e318196a40c Buy Metrics Abstract Methylentetrahydrofolate reductase C677T genotype was assessed in 35 patients of both sexes aged between 3.2 and 5.4 years affected by Wilms tumor (WT) and in 70 random controls. Statistical analysis was performed comparing frequency of WT methylentetrahydrofolate reductase genotypes with 70 controls and a larger Italian population. The homozygous TT and heterozygous CT genotypes were associated with a significantly higher frequency of WT than CC genotype. By reducing tissue folate concentrations and inducing hypomethylation both TT and CT genotypes could be risk factors for WT (odds ratio >1). © 2009 Lippincott Williams & Wilkins, Inc.