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Therapeutic Strategies for Targeting Mononuclear Phagocytes in Cancer

Dickens, David S. MD*; Jubinsky, Paul T. MD, PhD

Journal of Pediatric Hematology/Oncology: January 2009 - Volume 31 - Issue 1 - p 14-17
doi: 10.1097/MPH.0b013e31816e236a
Original Articles
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The initiation and progression of cancer is dependent on factors both intrinsic and extrinsic to the malignant cells. Stromal, vascular endothelial, and inflammatory cells are the principal normal populations that support tumors by supplying factors and nutrients. The mononuclear phagocyte lineage, which includes monocytes, macrophages, and dendritic cells is of particular clinical interest because lineage members can enhance tumor angiogenesis and metastasis, or alternately contribute to tumor destruction. Thus therapies that regulate these cells represent an innovative approach for improving patient survival in childhood cancer.

*Pediatric Hematology/Oncology, Helen DeVos Children's Hospital, Grand Rapids, MI

Pediatric Hematology/Oncology and Developmental and Molecular Biology, Albert Einstein College of Medicine and Children's Hospital at Montefiore, Bronx, NY

Reprints: Paul T. Jubinsky, MD, PhD, Albert Einstein College of Medicine, 1300 Morris Park Ave. C-510, Bronx, NY 10461 (e-mail: pjubinsk@aecom.yu.edu).

Received for publication November 9, 2007; accepted February 8, 2008

© 2009 Lippincott Williams & Wilkins, Inc.