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Focal Nodular Hyperplasia of the Liver in Patients Previously Treated for Pediatric Neoplastic Diseases

Marabelle, Aurélien MD, MSc*; Campagne, Denis MD; Déchelotte, Pierre MD‡ §; Chipponi, Jacques MD§ ∥; Deméocq, François MD§ ¶ ♯; Kanold, Justyna MD, PhD§ ¶ ♯

Journal of Pediatric Hematology/Oncology: July 2008 - Volume 30 - Issue 7 - p 546-549
doi: 10.1097/MPH.0b013e3181691709
Clinical and Laboratory Observations

The discovery of a liver nodule during postcancer follow-up suggests malignancy recurrence. However, patients previously treated for pediatric cancers are at greater risk of developing benign hepatic tumors, raising the problems of getting an accurate noninvasive diagnosis. Here we report 3 cases of focal nodular hyperplasia of the liver in patients previously treated for pediatric neoplastic diseases. Radiologic findings and needle-biopsies remained insufficient in 2 cases to rule out metastasis or a potentially threatening tumor. Only surgical resection led to positive diagnosis and prevented complications. However, a review of the literature shows that if the nodule presents with typical features of focal nodular hyperplasia a close imaging follow-up is all that is recommended.

*Département de Pédiatrie, Centre Léon Bérard, Lyon

Service de Radiologie Pédiatrique

Service d'Anatomo-pathologie

§Faculté de Médecine, Université Clermont1

Service de Chirurgie Viscérale

Service de Pédiatrie B et Unité, Bioclinique de Thérapie Cellulaire, Centre Hospitalier et Universitaire de Clermont-Ferrand

INSERM, CIC501, Clermont-Ferrand, France

The authors disclose no commercial affiliations or consultancies, stock or equity interests, and patent-licensing arrangements that could be considered to pose a conflict of interest regarding this article. Informed consent for publication has been obtained for each patient or their parents if under age of 18 years.

Reprints: Dr Aurelien Marabelle, MD, MSc, Département de Pédiatrie, Centre Léon Bérard, 28 rue Laennec, 69373 Lyon, France (e-mail:

Received for publication March 1, 2007; accepted January 14, 2008

© 2008 Lippincott Williams & Wilkins, Inc.