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Small Rounded B-cell Lymphoma of Bone Presented by Limp, With a Positive Multifocal 99 mTc MDP Bone Scintigraphy Pattern and a Negative 99 mTc HMPAO-labeled Leukocytes Study

Perez, Ruben Hernandez MD; Alonso Farto, Juan Carlos MD, PhD; Arias, Isabel Almoguera MD; Regi, Amanda Rotger MD; Perez Vazquez, Jose Manuel MD, PhD

Journal of Pediatric Hematology/Oncology: June 2008 - Volume 30 - Issue 6 - p 443-446
doi: 10.1097/MPH.0b013e318169169a
Original Articles

In this article, we present a rare case of B-cell bone lymphoma in a child with multifocal asymptomatic lesions detected by bone scintigraphy and a chronic clinical history characterized by limping and fever episodes for over a year. Initially, multifocal osteomyelitis was suspected and antibiotic therapy was administered with no clinical improvement. The biopsy of the main lesion in the left distal femur along with bone marrow cytology established the final diagnosis. This rare case illustrates the utility of routinely low cost-effective nuclear medicine studies like whole body bone scan and 99 mTc hexamethylpropyleneamine oxime-labeled leukocytes to orientate similar cases to a correct diagnosis.

Department of Nuclear Medicine, General University Hospital Gregorio Marañon, Madrid, Spain

Reprints: Dr Ruben Hernandez Perez, MD, Department of Nuclear Medicine, General University Hospital Gregorio Marañon, C/Doctor Esquerdo, 46 PC, 28009 Madrid, Spain (e-mail:

Received for publication March 22, 2007; accepted January 13, 2008

© 2008 Lippincott Williams & Wilkins, Inc.