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Mesenchymal Hamartoma of the Liver Mimicking Hepatoblastoma

Unal, Ekrem MD*; Koksal, Yavuz MD* †; Akcoren, Zuhal MD; Tavl, Lema MD§ı; Gunel, Engin MD; Kerimoglu, Ulku MD

Journal of Pediatric Hematology/Oncology: June 2008 - Volume 30 - Issue 6 - p 458-460
doi: 10.1097/MPH.0b013e318169171b
Clinical and Laboratory Observations

Mesenchymal hamartoma of the liver is a cystic benign liver mass occurring in children. Diagnostic confusion with hepatoblastoma may arise when α-feto–protein (AFP) level is elevated. We report an extremely rare case of mesenchymal hamartoma in an 11-month-old boy. Serum AFP was elevated and fine-needle aspiration biopsy suggested the lesion as hepatoblastoma, so he received preoperative chemotherapy. At the end of the preoperative chemotherapy, the tumor size and AFP level decreased. A right hepatectomy was performed. The pathologic examination of the specimen revealed mesenchymal hamartoma. Mesenchymal hamartoma of the liver with increased serum AFP levels may mimic hepatoblastoma if a cytological examination samples only the hepatocellular component of mesenchymal hamartoma. According to our knowledge, this is the first case of the mesenchymal hamartoma of the liver, which showed reduction in serum levels of AFP and involution of the tumor size by preoperative chemotherapy.

Departments of *Pediatrics

Division of Pediatric Oncology


Pediatric Surgery

Radiology, Selcuk University, Meram Faculty of Medicine, Konya

Pathology Unit, Faculty of Medicine, Department of Pediatrics, Hacettepe University, Ankara, Turkey

Reprints: Ekrem Unal, MD, Department of Pediatrics, Selcuk University, Meram Faculty of Medicine, 42080, Meram, Konya, Turkey (e-mail:

Received for publication March 2, 2007; accepted January 14, 2008

© 2008 Lippincott Williams & Wilkins, Inc.