Clinical and Laboratory ObservationsTransplantation of a Child With Sickle Cell Anemia With an Unrelated Cord Blood Unit After Reduced Intensity ConditioningMazur, Melissa MD*; Kurtzberg, Joanne MD*; Halperin, Edward MD†; Ciocci, Gilbert MSN*; Szabolcs, Paul MD* ‡Author Information *Department of Pediatrics, Pediatric Blood and Marrow Transplant Program Departments of †Immunology ‡Radiation Oncology and Pediatrics, Duke University Medical Center, Durham, NC 27705 Reprints: Paul Szabolcs, MD, Pediatric Blood and Marrow Transplant Program, Box 3350, Duke University Medical Center, Durham, NC 27705 (e-mail: [email protected]). Received for publication May 12, 2006; accepted October 9, 2006 Journal of Pediatric Hematology/Oncology: December 2006 - Volume 28 - Issue 12 - p 840-844 doi: 10.1097/MPH.0b013e31802d3e53 Buy Metrics Abstract Sickle cell disease can be corrected by hematopoietic cell transplantation but success is limited by low availability of matched related/unrelated donors and comorbidities leading to the increased transplant-related morbidity/mortality. There is a need for expanded donor pools and reduced intensity regimens. We describe a case of a second unrelated cord blood transplant after a novel preparative regimen in a child with sickle cell disease related stroke and liver fibrosis. Hydroxyurea, rituximab, and alemtuzumab were followed by thiotepa and low dose total body irradiation before unrelated cord blood transplant. Rapid full donor chimerism and improved performance status was achieved and sustained over 2 years after transplant. © 2006 Lippincott Williams & Wilkins, Inc.