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Kikuchi-Fujimoto Disease Is a Rare Cause of Lymphadenopathy and Fever of Unknown Origin in Children: Report of Two Cases and Review of the Literature

Scagni, Paola MD*; Peisino, Maria Grazia MD*; Bianchi, Maurizio MD; Morello, Maura MD*; Sardi, Nicola MD; Linari, Alessandra MD; Mastrodicasa, Luana MD; Madon, Enrico MD; Pecco, Paola MD*

Journal of Pediatric Hematology/Oncology: June 2005 - Volume 27 - Issue 6 - p 337-340
doi: 10.1097/01.mph.0000169250.49988.7f
Clinical and Laboratory Observations

Kikuchi-Fujimoto disease, a benign and unusual self-limiting histiocytic necrotizing lymphadenitis of unknown origin, should be included in the differential diagnosis of lymphadenopathy and fever of unknown origin. This disease mostly affects young Asian women and has rarely been reported in children, thus remaining a poorly recognized entity that is frequently confused with malignant lymphoma. The authors describe two children with Kikuchi-Fujimoto disease, with particular attention to diagnostic approach and clinical and histologic features of the disease.

From the *Department of Pediatrics, Children's Hospital Regina Margherita, Torino, Italy; †Pediatric Oncology Department, University of Torino, Torino, Italy; and ‡Department of Pathology, Children's Hospital Regina Margherita, Torino, Italy.

Received for publication March 16, 2005; accepted April 27, 2005.

Reprints: Scagni Paola, Ospedale Infantile Regina Margherita, Piazza Polonia 94, 10126 Torino, Italy (e-mail:

© 2005 Lippincott Williams & Wilkins, Inc.