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Severe Systemic Autoimmune Disease Associated With Epstein-Barr Virus Infection

Sevilla, Julián MD*; del Carmen Escudero, Maria MD*; Jiménez, Raquel MD; González-Vicent, Marta MD*; Manzanares, Javier MD; García-Novo, Dolores MD§; Madero, Luis MD*

Journal of Pediatric Hematology/Oncology: December 2004 - Volume 26 - Issue 12 - p 831-833
Clinical and Laboratory Observations

Infection with Epstein-Barr virus (EBV) has been associated with different autoimmune manifestations. The authors describe a girl who developed a severe systemic autoimmune disease with severe autoimmune hemolytic anemia, mild autoimmune thrombopenia, antineutrophil antibodies, and fatal autoimmune hepatitis after EBV infection. Despite immunosuppressive treatment and ultimately liver transplantation, this patient could not overcome her clinical condition and died. The etiopathogenesis of this complex disease and the association with EBV infection is discussed.

From *Pediatric Oncohematology, Hospital Niño Jesús, Madrid, Spain; †Pediatric Intensive Care Unit, Hospital Niño Jesús, Madrid, Spain; ‡Infant Gastroenterology and Hepatology, Hospital Universitario "Doce de Octubre" Madrid, Spain; and §Infant Gastroenterology Section, Hospital Niño Jesús, Madrid, Spain.

Received for publication January 12, 2004; accepted October 4, 2004.

Reprints: Julián Sevilla, MD, Oncohematología pediátrica, Hospital Niño Jesús, Menéndez Pelayo 65, Madrid 28009, Spain (e-mail:

© 2004 Lippincott Williams & Wilkins, Inc.