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Anaplastic Large Cell Lymphoma of the Pancreas: A Pediatric Case and Literature Review

Fraser, Christopher J. FRACP*; Chan, Yuen F. FRCPA; Heath, John A. FRACP, PhD*

Journal of Pediatric Hematology/Oncology: December 2004 - Volume 26 - Issue 12 - p 840-842
Clinical and Laboratory Observations
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A 13-year-old boy presented with acute abdominal pain and later became jaundiced. Medical imaging subsequently demonstrated a 7 × 8 cm pancreatic mass. Examination of a biopsy specimen obtained by open laparotomy revealed malignant lymphoma. Histology, immunohistochemistry, and cytogenetics confirmed the diagnosis of ALK1-positive anaplastic large cell lymphoma. He was treated with multiagent chemotherapy and remains in complete remission 12 months off treatment. This is the first case of primary pancreatic ALK1-positive anaplastic large cell lymphoma described in a child and shows that aggressive surgical resection of pancreatic tumors is not always necessary to achieve a cure.

From *Children's Cancer Centre, Royal Children's Hospital, Melbourne, Australia; and †Department of Anatomical Pathology, Women's and Children's Health, Melbourne, Australia.

Received for publication May 4, 2004; accepted October 13, 2004.

Reprints: Dr. John Heath, Children's Cancer Centre, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia (e-mail: john.heath@rch.org.au).

© 2004 Lippincott Williams & Wilkins, Inc.