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Soluble P-Selectin, Interleukin 6, and Thrombopoietin Levels in Children With Acute and Chronic Idiopathic Thrombocytopenic Purpura and Their Relationship With Mega-Dose Methylprednisolone Therapy: A Pilot Study

Olcay, Lale M.D.; Yenicesu, İdil M.D.; Yetgin, Sevgi M.D.

Journal of Pediatric Hematology/Oncology: December 2002 - Volume 24 - Issue 9 - p 742-745
ORIGINAL ARTICLES: Hematology
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We observed less severe symptoms in patients with chronic idiopathic thrombocytopenic purpura (ITP) than in patients with acute ITP with similar platelet counts. Thrombopoietin (TPO), soluble P-selectin, soluble P-selectin per platelet, and interleukin 6 (IL-6) were evaluated in children with ITP before treatment in 16 acute and 22 chronic cases and after treatment in 10 acute and chronic cases who received mega-dose methylprednisolone. The levels of IL-6, soluble P-selectin, soluble P-selectin per platelet, and platelet count were similar in acute and chronic ITP (P > 0.05) but TPO in acute ITP was higher than that of the patients with chronic ITP (P < 0.05). The posttreatment IL-6 and TPO declined (P < 0.05), but soluble P-selectin and platelet count increased (P < 0.05). Posttreatment soluble P-selectin per platelet levels were higher than the normal values (P < 0.05). These results suggest that IL-6, soluble P-selectin, and soluble P-selectin per platelet are not responsible for the milder symptoms in chronic than in acute ITP. Mega-dose methylprednisolone seems to keep the soluble P-selectin levels elevated.

From the Ankara Oncology Hospital (L.O.), Demetevler, Ankara; and Pediatric Hematology (I.Y., S.Y.), Hacettepe University İhsan Doğramaci Children's Hospital, Pediatric Hematology Unit, Ankara, Turkey.

Submitted for publication October 23, 2001; accepted October 23, 2001.

Address correspondence and reprint requests to Sevgi Yetgin, M.D., Hacettepe University İhsan Doğramaci Children's Hospital, Pediatric Hematology Unit, 06100, Ankara, Turkey. E-mail: laleolcay@ hotmail.com.

© 2002 Lippincott Williams & Wilkins, Inc.