Venous thrombosis of transverse and sigmoid sinuses was diagnosed in a 3-year-old child who is a carrier of the G20210A prothrombin gene mutation. Recombinant tissue plasminogen activator (rt-PA) treatment was started 9 days following the onset of neurologic signs. Nine days of rt-PA therapy completely dissolved the thrombus. This case provides further evidence that rt-PA is useful and safe in children with thrombosis.
Fromthe Department of Pediatrics, La Sapienza University, Rome, Italy (L.T., M.I., M.P.S., M.C.T., G.R., L.B.); and the Department of Hematology, Catholic University, Rome, Italy (V.D.S.).
Submitted for publication June 18, 2001; accepted September 20, 2001.
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