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Recombinant Plasminogen Activator Therapy for Cerebral Vein Thrombosis in a Child Carrier of Prothrombin Gene Mutation

Tarani, Luigi M.D.; Iacobini, Metello M.D.; De Stefano, Valerio M.D.; Smacchia, Maria Paola M.D.; Tozzi, Maria Cristina M.D.; Raguso, Grazia M.D.; Bruni, Lida M.D.

Journal of Pediatric Hematology/Oncology: December 2002 - Volume 24 - Issue 9 - p 769-771
Clinical And Laboratory Observations

Venous thrombosis of transverse and sigmoid sinuses was diagnosed in a 3-year-old child who is a carrier of the G20210A prothrombin gene mutation. Recombinant tissue plasminogen activator (rt-PA) treatment was started 9 days following the onset of neurologic signs. Nine days of rt-PA therapy completely dissolved the thrombus. This case provides further evidence that rt-PA is useful and safe in children with thrombosis.

Fromthe Department of Pediatrics, La Sapienza University, Rome, Italy (L.T., M.I., M.P.S., M.C.T., G.R., L.B.); and the Department of Hematology, Catholic University, Rome, Italy (V.D.S.).

Submitted for publication June 18, 2001; accepted September 20, 2001.

Address correspondence and reprint requests to Luigi Tarani, Clinica Pediatrica Università, La Sapienza, viale Regina Elena 324, 00161 Rome, Italy. E-mail:

© 2002 Lippincott Williams & Wilkins, Inc.