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Cutaneous EBV-Related Lymphoproliferative Disorder in a 15-Year-Old Boy With AIDS: An Unusual Clinical Presentation

Fardet, Laurence M.D.; Blanche, Stéphane M.D., Ph.D.; Brousse, Nicole M.D.; Bodemer, Christine M.D.; Fraitag, Sylvie M.D.

Journal of Pediatric Hematology/Oncology: November 2002 - Volume 24 - Issue 8 - p 666-669
Clinical And Laboratory Observations

Lymphomas are a well-known malignancy in individuals with human immunodeficiency virus type 1 (HIV-1) infection. Most lymphomas are of B-cell lineage and cutaneous involvement is rare. Cutaneous T-cell lymphomas have been previously described in adults with HIV-1 infection but are exceptional in HIV-1 infected–children. The authors report here the extremely rare case of a large-cell cutaneous lymphoproliferation of T-cell lineage expressing Epstein-Barr virus (EBV) antigens in a 15-year-old boy with AIDS and his uncommon clinical presentation. The atypical clinical evolution with a nonaggressive treatment emphasizes that for immunosuppressed patients, the diagnosis of immunosuppression-related lymphoproliferative disorder should be considered before giving the diagnosis of malignant lymphoma when tumoral lymphoid cells express EBV antigens.

From the Department of Pathology (L.F., N.B., S.F.), the Department of Hematology/Immunology (S.B.), and the Department of Dermatology (C.D.), Hopital Necker-Enfants Malades, Paris, France.

Submitted for publication June 6, 2001; accepted September 21, 2001.

Address correspondence and reprint requests to Sylvie Fraitag, M.D., service d'anatomopathologie, hôpital Necker-Enfants Malades, 149 rue de Sevres 75015, Paris, France. E-mail:

© 2002 Lippincott Williams & Wilkins, Inc.