Clinical And Laboratory ObservationsNumb Chin Syndrome in Ewing SarcomaAntunes, Nuno Lobo M.D.; Gorlick, Richard M.D.; Callaja, Elizabeth M.D.; Lis, Eric M.D. Author Information From the Department of Pediatrics (N.L.A., R.G., E.C.) and Neuroradiology (E.L.), Memorial Sloan-Kettering Cancer Center, New York, New York, U.S.A. Submitted for publication August 4, 1999; accepted December 7, 1999. Address correspondence and reprint requests to Dr. Nuno Lobo Antunes, Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021. Journal of Pediatric Hematology/Oncology: November 2000 - Volume 22 - Issue 6 - p 521-523 Buy Abstract The numb chin syndrome consists of unilateral hypesthesia of the chin and lower lip. In adults, it is often associated with metastatic disease to the mandible, base of the skull, or leptomeninges. In children, it has been associated with infiltration of the inferior alveolar nerve by leukemic cells. We describe two cases of numb chin syndrome in children with Ewing sarcoma. In a child with a solid tumor, this symptom seems to have an ominous meaning and should lead to the investigation of progressive skeletal involvement. © 2000 Lippincott Williams & Wilkins, Inc.