Research ReportsDeveloping an Epidemiologic Study to Investigate Risk Factors for Colorectal Cancer Among Alaska Native PeopleNash, Sarah H. PhD; Peters, Ulrike PhD; Redwood, Diana PhDAuthor Information Alaska Native Epidemiology Center, Alaska Native Tribal Health Consortium, Anchorage, Alaska (Drs Nash and Redwood); Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington (Dr Peters); and School of Public Health, University of Washington, Seattle, Washington (Dr Peters). Correspondence: Sarah H. Nash, PhD, Alaska Native Epidemiology Center, Alaska Native Tribal Health Consortium, 3900 Ambassador Dr, Anchorage, AK 99508 ([email protected]). This study was funded by the National Institute of General Medical Sciences of the National Institutes of Health (NIH) under award no. U54GM115371. Dr Nash is additionally funded by the National Cancer Institute (NCI) Surveillance, Epidemiology and End Results Program under contract no. HHSN261201800014I. Dr Redwood is supported by the Centers for Disease Control and Prevention (CDC) Building Public Health Infrastructure for Alaska Native People Component A (Cooperative Agreement no. 1 NU58DP006379). Dr Peters is supported by the NCI (U01 CA137088, U01 CA164930, U01 CA185094, R01 CA201407, and R01 CA206279). The authors thank the Alaska Native Tribal Health Consortium Board of Directors for their contributions and support.The content presented herein is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the CDC.The authors declare no conflicts of interest. Journal of Public Health Management and Practice: September/October 2019 - Volume 25 - Issue - p S54-S60 doi: 10.1097/PHH.0000000000000994 Buy Metrics Abstract Alaska Native (AN) people have among the highest rates of colorectal cancer (CRC) recorded globally. Preventing CRC is an important health priority of AN tribal health leaders and communities. Lifestyle and genetic risk and protective factors for CRC among AN people remain understudied. We have been working to establish a tribally led, community-based, comprehensive investigation of lifestyle and genetic risk and protective factors for CRC among AN people. We describe the process of initiating this research study, including conversations with key tribal health system staff. We discuss themes that arose during these conversations and literature review and describe how those themes were used during the study design and protocol development phase. This description is intended to provide guidance to other researchers working to establish community-based studies of cancer risk, particularly among tribal communities. © 2019 Wolters Kluwer Health, Inc. All rights reserved.